Should be used with caution among athletes.
[Drug name]
Generic name: Tibolone 2.5 mg Tablets
English name: Tibolone 2.5 mg Tablets
[Composition]
The main ingredient of this product is tibolone, its chemical name is 7 α-methyl-17 β-hydroxy-19-norpregn-17 α-pregn-5 (10)-en-20-yn-3-one.
[Description]
The substance is a white tablet.
[Indications]
Menopause syndrome caused by natural menopause and surgical menopause, such as hot flashes, sweating, etc.
[Posology and Method of Administration]
This product should be swallowed as a whole, not chewed, and preferably taken at the same time every day. At a dose of one tablet (2.5 mg) a day, symptoms generally improve within a few weeks, but optimal results are obtained after at least three months of continuous use. According to this recommended dose, under the guidance of a doctor, it can be continuously taken for a long term.
[Pharmacological Effect]
This product stabilizes the hypothalamo-pituitary system in women after the decline of ovarian function during menopause, and this central effect is the combined result of the multiple hormonal properties of this product, i.e., this product has both estrogenic activity, progestational activity and weak androgenic activity.
After oral administration, this product is rapidly metabolized into three compounds leading to its pharmacological effects. 3 α-OH and 3 β-0H metabolites have mainly estrogenic activity, and △4-isomer and the parent compound have predominantly progestogenic and androgenic activity. This product has obvious tissue-specific effect, and presents with estrogenic effect in the bone, brain temperature center (hot flashes) and vagina; In breast tissue, it has obvious progestational and anti-estrogenic effects; It exhibits mild androgenic and progestational effects in the endometrium.
At a daily oral dose of 2.5 mg, this product can suppress gonadotropin levels in postmenopausal women and suppress ovulation in women of childbearing potential. This dose did not stimulate the endometrium of postmenopausal women, and only mild proliferation was observed in a very small number of patients. The degree of proliferation did not increase with the time of administration. Irritation of this product to the vaginal mucosa was also observed.
The same dose of this product inhibits bone loss in postmenopausal women. Menopausal symptoms, especially vasomotor symptoms such as hot flashes, sweating, etc. are inhibited, and it also has a good effect on libido and mood.
[Storage]
Store airtight in a dark place (not more than 20°C).
[Package]
Aluminum-plastic package, 7 tablets per sheet, 1 sheet per pack.
Aluminum-plastic package, 7 tablets per sheet, 4 sheets per pack.
[Shelf Life]
24 months
