In the 1960s and 1970s, Beijing No.3 Pharmaceutical Factory, the predecessor of the company initiated the development of 18-methylnorgestrel, a critical API used for contraceptives and became the first national approved manufacturer of this API a year later. The success of this project filled the gap of oral contraceptive API in China, had epoch-making significance, opened a new chapter for China's industry, and won the "National Science Congress Award" in March 1978.

To meet the requirements of urban planning, the manufacture site is relocated to current address, No. 27 Chaoyang North Road, Chaoyang District, Beijing, China. The production in the new manufacture site started on 1 March 1996.

Beijing No. 3 Pharmaceutical Factory was restructured into Beijing Zizhu Pharmaceutical Company Limited in 2000, entering a new stage. The restructuring was in accordance with the State Council's policy on debt-to-equity conversion of partial state-owned enterprises, and approved by the State Economic and Trade Commission and the Beijing Municipal Economic Commission.

The API production base in Qinhuangdao was built in 2008 based on international development strategical need and Beijing industrial development plan, which guarantees the reliability of API sources for company’s finished products.

The company officially changed its name to China Resources Zizhu Pharmaceutical Co., Ltd. and has become a wholly owned subsidiary of China Resources Pharmaceutical Group since then, entering a brand new stage of development.

Beijing United Pharmaceutical completed the resumption of production and related GMP certification under CRZP’s guidance. The Class II new drug Epalrestat API and finished product were successfully marketed, becoming a billion-dollar variety for CRZP and injecting new momentum into the specialty area.

CRZP was selected as a National Green Factory during the event organized by the Ministry of Industry and Information Technology, aiming at implementing "Made in China 2025" and "Industrial Green Development Plan", accelerating the construction of green manufacturing system and creating advanced models of green manufacturing enterprises.

Committing to human life and health industry, CRZP develops, manufactures and markets pharmaceuticals and health products revolving around female health, characteristic specialties, APIs and international business.