[Drug name]
Generic name: Moxifloxacin Hydrochloride Eye Drops
English name: Moxifloxacin Hydrochloride Eye Drops
[Composition]
The main ingredient of this product is moxifloxacin hydrochloride.
Chemical name: 1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-[(4aS, 7aS)-octahydro-6H-pyrrolo [3, 4-b] pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride
Excipients: sodium chloride, boric acid, sodium hydroxide and/or hydrochloric acid, water for injections.
[Description]
A clear, pale yellowish-green liquid.
[Indications]
For the treatment of bacterial conjunctivitis caused by the following susceptible organisms:
Gram +:
Corynebacterium sp.*
Micrococcus luteus*
Staphylococcus aureus
S.epidermidis
Staphylococcus haemolyticus
Staphylococcus hominis
Staphylococcus warneri*
Streptococcus pneumoniae
Streptococcus viridans
Gram-negative bacteria:
Acinetobacter lwoffi*
Haemophilus influenzae
Haemophilus parainfluenzae*
A.baumannii
Acn.Junii*
Stenotrophomonas maltophilia*
Chryseobacterium spp.*
Other micro-organisms:
Chlamydia trachomatis
* The number of studies on efficacy in infections with this type of microorganism was less than 10.
[Strength]
0.5% (5ml: 25mg, as C
21H24FN3O4)
[Posology and Method of Administration]
Instill 1 drop in the affected eye (s) 3 times daily for 7 consecutive days.
[Pharmacological Effect]
Moxifloxacin is an 8-methoxyfluoroquinolone antibacterial agent with broad spectrum of activity and bactericidal action. Moxifloxacin has shown broad-spectrum of antibacterial activity in vitro against Gram-positive, Gram-negative, anaerobic, acid-resistant and atypicalmicroorganisms such as mycoplasma, chlamydia and legionella.
Moxifloxacin inhibits topoisomerases II (DNA gyrase) and IV. Topoisomerases are key enzymes that control DNA topology and are involved in DNA replication, repair and transcription.
Moxifloxacin presents with concentration-dependent bactericidal activity. The minimum bactericidal concentration and minimum inhibitory concentration were basically the same.
[Storage]
Store at 2 ℃ ~ 30 ℃.
Use within 28 days after unpacking and discard after expiration date.
[Package]
Low density polyethylene medical eye drops bottle, 1 bottle/box.
[Shelf Life]
24 months
